Secrets of Cancer! #MustRead #CancerAwareness

Key facts

Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths.

The most common cancers are breast, lung, colon and rectum and prostate cancers.

Around one-third of deaths from cancer are due to tobacco use, high body mass index, alcohol consumption, low fruit and vegetable intake, and lack of physical activity.

Cancer-causing infections, such as human papillomavirus (HPV) and hepatitis, are responsible for approximately 30% of cancer cases in low- and lower-middle-income countries.

Many cancers can be cured if detected early and treated effectively.

Overview

Cancer is a generic term for a large group of diseases that can affect any part of the body. Other terms used are malignant tumours and neoplasms. One defining feature of cancer is the rapid creation of abnormal cells that grow beyond their usual boundaries, and which can then invade adjoining parts of the body and spread to other organs; the latter process is referred to as metastasis. Widespread metastases are the primary cause of death from cancer.

The problem

Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020 (1). The most common in 2020 (in terms of new cases of cancer) were:

  • breast (2.26 million cases);
  • lung (2.21 million cases);
  • colon and rectum (1.93 million cases);
  • prostate (1.41 million cases);
  • skin (non-melanoma) (1.20 million cases); and
  • stomach (1.09 million cases).

The most common causes of cancer death in 2020 were:

  • lung (1.80 million deaths);
  • colon and rectum (916 000 deaths);
  • liver (830 000 deaths);
  • stomach (769 000 deaths); and
  • breast (685 000 deaths).

Each year, approximately 400 000 children develop cancer. The most common cancers vary between countries. Cervical cancer is the most common in 23 countries.

Causes

Cancer arises from the transformation of normal cells into tumour cells in a multi-stage process that generally progresses from a pre-cancerous lesion to a malignant tumour. These changes are the result of the interaction between a person’s genetic factors and three categories of external agents, including:

  • physical carcinogens, such as ultraviolet and ionizing radiation;
  • chemical carcinogens, such as asbestos, components of tobacco smoke, alcohol, aflatoxin (a food contaminant), and arsenic (a drinking water contaminant); and
  • biological carcinogens, such as infections from certain viruses, bacteria, or parasites.

WHO, through its cancer research agency, the International Agency for Research on Cancer (IARC), maintains a classification of cancer-causing agents.

The incidence of cancer rises dramatically with age, most likely due to a build-up of risks for specific cancers that increase with age. The overall risk accumulation is combined with the tendency for cellular repair mechanisms to be less effective as a person grows older.

Risk factors

Tobacco use, alcohol consumption, unhealthy diet, physical inactivity and air pollution are risk factors for cancer and other noncommunicable diseases.

Some chronic infections are risk factors for cancer; this is a particular issue in low- and middle-income countries. Approximately 13% of cancers diagnosed in 2018 globally were attributed to carcinogenic infections, including Helicobacter pylori, human papillomavirus (HPV), hepatitis B virus, hepatitis C virus, and Epstein-Barr virus (2).

Hepatitis B and C viruses and some types of HPV increase the risk for liver and cervical cancer, respectively. Infection with HIV increases the risk of developing cervical cancer six-fold and substantially increases the risk of developing select other cancers such as Kaposi sarcoma.

Reducing the burden

Between 30 and 50% of cancers can currently be prevented by avoiding risk factors and implementing existing evidence-based prevention strategies. The cancer burden can also be reduced through early detection of cancer and appropriate treatment and care of patients who develop cancer. Many cancers have a high chance of cure if diagnosed early and treated appropriately.

Prevention

Cancer risk can be reduced by:

  • not using tobacco;
  • maintaining a healthy body weight;
  • eating a healthy diet, including fruit and vegetables;
  • doing physical activity on a regular basis;
  • avoiding or reducing consumption of alcohol;
  • getting vaccinated against HPV and hepatitis B if you belong to a group for which vaccination is recommended;
  • avoiding ultraviolet radiation exposure (which primarily results from exposure to the sun and artificial tanning devices) and/or using sun protection measures;
  • ensuring safe and appropriate use of radiation in health care (for diagnostic and therapeutic purposes);
  • minimizing occupational exposure to ionizing radiation; and
  • reducing exposure to outdoor air pollution and indoor air pollution, including radon (a radioactive gas produced from the natural decay of uranium, which can accumulate in buildings — homes, schools and workplaces).

Early detection

Cancer mortality is reduced when cases are detected and treated early. There are two components of early detection: early diagnosis and screening.

Early diagnosis

When identified early, cancer is more likely to respond to treatment and can result in a greater probability of survival with less morbidity, as well as less expensive treatment. Significant improvements can be made in the lives of cancer patients by detecting cancer early and avoiding delays in care.

Early diagnosis consists of three components:

  • being aware of the symptoms of different forms of cancer and of the importance of seeking medical advice when abnormal findings are observed;
  • access to clinical evaluation and diagnostic services; and
  • timely referral to treatment services.

Early diagnosis of symptomatic cancers is relevant in all settings and the majority of cancers. Cancer programmes should be designed to reduce delays in, and barriers to, diagnosis, treatment and supportive care.

Screening

Screening aims to identify individuals with findings suggestive of a specific cancer or pre-cancer before they have developed symptoms. When abnormalities are identified during screening, further tests to establish a definitive diagnosis should follow, as should referral for treatment if cancer is proven to be present.

Screening programmes are effective for some but not all cancer types and in general are far more complex and resource-intensive than early diagnosis as they require special equipment and dedicated personnel. Even when screening programmes are established, early diagnosis programmes are still necessary to identify those cancer cases occurring in people who do not meet the age or risk factor criteria for screening.

Patient selection for screening programmes is based on age and risk factors to avoid excessive false positive studies. Examples of screening methods are:

  • HPV test (including HPV DNA and mRNA test), as preferred modality for cervical cancer screening; and
  • mammography screening for breast cancer for women aged 50–69 residing in settings with strong or relatively strong health systems.

Quality assurance is required for both screening and early diagnosis programmes.

Treatment

A correct cancer diagnosis is essential for appropriate and effective treatment because every cancer type requires a specific treatment regimen. Treatment usually includes surgery, radiotherapy, and/or systemic therapy (chemotherapy, hormonal treatments, targeted biological therapies). Proper selection of a treatment regimen takes into consideration both the cancer and the individual being treated. Completion of the treatment protocol in a defined period of time is important to achieve the predicted therapeutic result.

Determining the goals of treatment is an important first step. The primary goal is generally to cure cancer or to considerably prolong life. Improving the patient’s quality of life is also an important goal. This can be achieved by support for the patient’s physical, psychosocial and spiritual well-being and palliative care in terminal stages of cancer.

Some of the most common cancer types, such as breast cancer, cervical cancer, oral cancer, and colorectal cancer, have high cure probabilities when detected early and treated according to best practices.

Some cancer types, such as testicular seminoma and different types of leukaemia and lymphoma in children, also have high cure rates if appropriate treatment is provided, even when cancerous cells are present in other areas of the body.

There is, however, a significant variation in treatment availability between countries of different income levels; comprehensive treatment is reportedly available in more than 90% of high-income countries but less than 15% of low-income countries (3).

Palliative care

Palliative care is treatment to relieve, rather than cure, symptoms and suffering caused by cancer and to improve the quality of life of patients and their families. Palliative care can help people live more comfortably. It is particularly needed in places with a high proportion of patients in advanced stages of cancer where there is little chance of cure.

Relief from physical, psychosocial, and spiritual problems through palliative care is possible for more than 90% of patients with advanced stages of cancer.

Effective public health strategies, comprising community- and home-based care, are essential to provide pain relief and palliative care for patients and their families.

Improved access to oral morphine is strongly recommended for the treatment of moderate to severe cancer pain, suffered by over 80% of people with cancer in the terminal phase.

More : https://www.who.int/news-room/fact-sheets/detail/cancer

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FAQ's

There isn't a single biggest cause. While genetics play a role, around one-third of cancer deaths are linked to modifiable risk factors according to the World Health Organization. These include:
- Tobacco use: This is the single greatest preventable cause of cancer, linked to lung cancer and many others.
- Unhealthy diet: Poor diet lacking fruits, vegetables, and whole grains, but high in processed meats, can increase cancer risk.
- Physical inactivity: Regular exercise is crucial! Studies suggest it can lower the risk of colon, breast, and endometrial cancers.
- Obesity: Excess weight is a risk factor for various cancers.
- Certain infections: Chronic infections with viruses like HPV or Hepatitis can increase cancer risk.

- Cancer typically starts when normal cells undergo genetic mutations that cause them to grow and divide uncontrollably. These mutations can result from various factors such as exposure to carcinogens,genetic predisposition, viral infections, or lifestyle factors.

- Cancer weakness refers to vulnerabilities in cancer cells that can be targeted for treatment. These weaknesses may include specific genetic mutations or cellular processes that are essential for cancer cell survival and proliferation. Targeting these weaknesses with therapies such as chemotherapy, targeted therapy, or immunotherapy can help kill cancer cells or slow their growth.

- Warning signs of cancer include persistent changes in the body that are not normal for the individual, such as unexplained weight loss, lumps or thickening in the breast or other parts of the body, changes in bowel or bladder habits, persistent cough or hoarseness, unexplained bleeding or bruising, and prolonged fatigue or weakness. It's important to consult a healthcare professional if you experience any of these symptoms.

- While not all cancers can be prevented, certain lifestyle changes and preventive measures can reduce the risk of developing cancer. These include avoiding tobacco use, maintaining a healthy diet and weight, limiting alcohol consumption, protecting against UV radiation exposure, getting vaccinated against cancer-causing viruses , and participating in cancer screening programs for early detection.

- Cancer is diagnosed through a combination of medical history evaluation, physical examination, imaging tests , laboratory tests , and specialized procedures. The specific diagnostic approach depends on the type and location of cancer suspected.

- Cancer staging is a process used to describe the extent and spread of cancer within the body. The stages range from stage 0 to stage IV . Staging helps determine prognosis and guides treatment decisions.

- Treatment options for cancer vary depending on the type, stage, and location of cancer, as well as the individual's overall health and preferences. Common treatment modalities include surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, and stem cell transplant. Treatment plans are often personalized based on the specific characteristics of each case.

- Cancer awareness and education play a crucial role in early detection, prevention, and treatment outcomes. By raising awareness about risk factors, warning signs, screening guidelines, and available resources, individuals can make informed decisions about their health, seek timely medical attention, and support ongoing research efforts to improve cancer prevention, detection, and treatment strategies.

- Maintain a healthy lifestyle: Eat a balanced diet, exercise regularly, and maintain a healthy weight.
- Limit tobacco use: Quitting smoking significantly reduces cancer risk.
- Limit alcohol consumption: Excessive alcohol intake can increase cancer risk.
- Get vaccinated: Vaccines can protect against certain cancers caused by viruses like HPV.
- Schedule regular checkups and screenings: Early detection is crucial for successful treatment.

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